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The research programs of the Division of Hematology/Oncology focus on functional genomics in hematologic diseases, dendritic cell therapy and erythropoiesis. The director of this division, Hyeoung-Joon Kim, is also the principle investigator of The Genomic Research Center for Hematopoietic Diseases. The Genomic Research Center for Hematopoietic Diseases is the one of the leading genomic research center set up in 2001 by CNUH and the Ministry of Health and Welfare, Republic of Korea in order to narrow the gap between sequence and function of the human leukemia. This program will underpin biologic and medical research worldwide on hematiopoietic diseases. For detailed informations about this division and The Genomic Research Center for Hematopoietic Diseases visit http://medicine.jnu.ac.kr/department/hd and http://grace.chonnam.ac.kr/~gens. Functional genomics in hematopoietic diseases
Detection of genes related with leukemogenesis using cDNA microarray
SNP (single nucleotide polymorphism) associated with gene regulation and splicing of gene transcript in hematopoietic diseases
Development of DNA chip kit for specific functional genes associated with leukemia
Analysis of proteins related with treatment resistant or relapse using proteomics
Interaction map for counteracting proteins related with treatment resistant or relapse
Development of protein chip kit for diagnosis proteins related with treatment resistant or relapse
Detection of minimal residual disease (MRD) using multiparametric flow cytometry and RQ-PCR in hematopoietic diseases
Dendritic cell therapy
Generation of leukemic-dendritic cells from acute myeloid leukemia patients using cytokine combinations or calcium ionophore
Induction of leukemic-specific cytotoxic responses by autologous monocyte-derived dendritic cells presenting with acute myeloid leukemic cell antigen
s Immunotherapy using donor CD8+ T cells stimulated with leukemic cell- or donor CD14+ cell-derived dendritic cells against leukemia relapsing after hematopoietic stem cel
l transplantation Immunotherapy using autologous CD14+ cell-derived dendritic cells pulsed with tumor lysates for acute myeloid leukemia relapsing after autologous peripheral blood stem cell transplantation
Human erythropoiesis
Proliferating and anti-apoptotic effects of SCF on human erythroid progenitor cells PI-3/Akt dependant activation of cFLIP by SCF in human erythroid progenitor cells
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